FORMULATION AND EVALUATION OF BILAYERED FELODIPINE TRANSDERMAL PATCHES: IN VITRO AND EX VIVO CHARACTERIZATION

Objective: Felodipine (FD) is an effective Biopharmaceutics Classification System Class II calcium channel blocker mainly used in the management of hypertension and angina pectoris. It has poor solubility low oral bioavailability (15%). To overcome these disadvantages to maintain constant plasma concentration for maximum therapeutic activity, there a need design alternative route, that is, transdermal route. The pharmacokinetic parameters make FD suitable candidate delivery. present investigation consists study vitro ex vivo skin flux from bilayered patches.
 Methods: patches were fabricated by solvent casting method using hydrophilic hydrophobic polymer with different composition. Tween 80 incorporated as solubilizer, polyethylene glycol 600 plasticizer, menthol, eucalyptus oil, lemongrass oil permeation enhancers, respectively. prepared drug delivery system was extensively evaluated release, through pig ear skin, moisture content, absorption, water vapor transmission, mechanical properties. physicochemical interaction between polymers investigated Fourier-transform infrared (FTIR) spectroscopy.
 Results: All formulations exhibited satisfactory characteristics. A 35.2 μg/cm2 h, 27.9 25.25 h achieved optimized containing respectively, enhances. Values tensile strength (0.0652±0.034 kg/mm²) elongation at break (0.8749±0.0.0029% mm²) revealed formulation F9 strong but not brittle. Drug excipients compatibility studies showed no evidence active ingredient polymers.
 Conclusion: Bilayered could be required